Nomograms incorporating primary tumor response at mid-radiotherapy to predict survival in locoregionally advanced nasopharyngeal carcinoma.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 37204765.
- Also identified by DOI 10.1002/hed.27404.
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Abstract
A nomogram that incorporates tumor response at mid-radiotherapy (mid-RT) to predict the prognosis of locoregionally advanced nasopharyngeal carcinoma (LA-NPC) has not been established. This study retrospectively reviewed 583 patients with LA-NPC who underwent magnetic resonance imaging scans at mid-RT (the fourth week of RT) between 2015 and 2019. Primary tumor (PT) response at mid-RT was found to predict disease-free survival (DFS) and overall survival (OS). Independent factors from multivariable analysis to predict DFS and OS were assembled into nomograms with (nomograms A<sub>mid-RT</sub> and B<sub>mid-RT</sub> ) or without (nomograms A<sub>baseline</sub> and B<sub>baseline</sub> ) PT response. Internal validation revealed good performance of these nomograms in discrimination: C-statistics = 0.761 for nomogram A<sub>mid-RT</sub> and 0.809 for nomogram B<sub>mid-RT</sub> , which showed better discrimination performance than (C-statistics: 0.755) nomogram A<sub>baseline</sub> and (C-statistics: 0.798) nomogram B<sub>baseline</sub> (Z-statistic = 2.476, p < 0.05; Z-statistic = 1.971, p < 0.05). The nomograms based on PT response at mid-RT showed favorable predictive accuracy for DFS and OS in patients with LA-NPC.
Medical subject headings
- Nomograms
- Nasopharyngeal Neoplasms