Real-Time Identification of Nodal Metastases With 99m Tc-Prostate-Specific Membrane Antigen-Based Radioguidance and Indocyanine Green Fluorescence Imaging in Primary Prostate Cancer Surgery-On the Road to Hybrid Image-Guided Surgery.

de Barros, Hilda A; van Oosterom, Matthias N; van Leeuwen, Fijs W B; van der Poel, Henk G; van Leeuwen, Pim J · Clin Nucl Med · 2023

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Abstract

Recent developments in image-guided prostate cancer surgery focus on extending prostate-specific membrane antigen-directed radioguidance with optical tumor detection using fluorescence, as radio- and fluorescence signals complement each other with in-depth detection and real-time visualization, respectively. As a step in this direction, we report here the integration of indocyanine green fluorescence imaging into a 99m Tc-prostate-specific membrane antigen-targeted radioguided surgery workflow.

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