Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images.
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- Record sourced from PubMed, PMID 37262162.
- Also identified by DOI 10.1126/science.abn6598 and PMC identifier 11987082.
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Abstract
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and functional networks. We identified 80 associated genomic loci (<i>P</i> < 6.09 × 10<sup>-10</sup>) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.
Medical subject headings
- Brain
- Heart
- Cardiovascular Diseases
- Brain Diseases