T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure.

Iwase, Saori C; Edlefsen, Paul T; Bhebhe, Lynnette; Motsumi, Kesego; Moyo, Sikhulile; Happel, Anna-Ursula; Shao, Danica; Mmasa, Nicholas et al. · Clin Infect Dis · 2023

cross_sectional · Level IV

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Abstract

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

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