Novel Gadolinium-Free Ultrasmall Nanostructured Positive Contrast for Magnetic Resonance Angiography and Imaging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37300521.
- Also identified by DOI 10.1021/acs.nanolett.3c00665 and PMC identifier 10312191.
- Licence recorded as CC BY-NC-ND.
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Abstract
Nanostructured contrast agents are promising alternatives to Gd<sup>3+</sup>-based chelates in magnetic resonance (MR) imaging techniques. A novel ultrasmall paramagnetic nanoparticle (UPN) was strategically designed to maximize the number of exposed paramagnetic sites and <i>r</i><sub>1</sub> while minimizing <i>r</i><sub>2</sub>, by decorating 3 nm titanium dioxide nanoparticles with suitable amounts of iron oxide. Its relaxometric parameters are comparable to those of gadoteric acid (GA) in agar phantoms, and the <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratio of 1.38 at 3 T is close to the ideal unitary value. The strong and prolonged contrast enhancement of UPN before renal excretion was confirmed by <i>T</i><sub>1</sub>-weighted MR images of Wistar rats after intravenous bolus injection. Those results associated with good biocompatibility indicate its high potential as an alternative blood-pool contrast agent to the GA gold standard for MR angiography, especially for patients with severe renal impairment.
Medical subject headings
- Contrast Media
- Magnetic Resonance Angiography