Keeping It in the Family: HER3 as a Target in Brain Metastases.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 37306554.
- Also identified by DOI 10.1158/1078-0432.CCR-23-1107.
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Abstract
In 180 patients with metastatic breast cancer and non-small cell lung cancer (NSCLC), HER3 expression was found in >70% of brain metastases (BM). HER3-targeting antibody-drug conjugates have demonstrated efficacy in HER3-expressing metastatic breast cancer and NSCLC. Thus, HER3 expression by IHC may be a biomarker for development of HER3-targeting BM-specific therapeutics. See related article by Tomasich et al., p. 3225.
Medical subject headings
- Lung Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Brain Neoplasms
- Breast Neoplasms