Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution.
basic_science · Level V
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- Record sourced from PubMed, PMID 37319212.
- Also identified by DOI 10.1126/science.adg0934 and PMC identifier 10829769.
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Abstract
Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging <i>Drosophila</i>. We characterized 163 distinct cell types and performed an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities. We further developed aging clock models to predict fly age and show that ribosomal gene expression is a conserved predictive factor for age. Combining all aging features, we find distinctive cell type-specific aging patterns. This atlas provides a valuable resource for studying fundamental principles of aging in complex organisms.
Medical subject headings
- Aging
- Cellular Senescence
- Drosophila melanogaster