Extracellular HSP90 warms up integrins for an irisin workout.
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- Record sourced from PubMed, PMID 37327790.
- Also identified by DOI 10.1016/j.cmet.2023.06.002 and PMC identifier 10593114.
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Abstract
The hormone-like protein irisin is involved in browning of adipose tissue and regulation of metabolism. Recently, Mu et al. identified the extracellular chaperone heat shock protein-90 (Hsp90) as the activating factor for "opening" αVβ5 integrin receptor, allowing for high-affinity irisin binding and effective signal transduction.
Medical subject headings
- Fibronectins
- Integrins