The ROSA-Like Prophage Colonizing Staphylococcus aureus Promotes Intracellular Survival, Biofilm Formation, and Virulence in a Chronic Wound Environment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37343134.
- Also identified by DOI 10.1093/infdis/jiad218.
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Abstract
The transition from colonization to invasion is critical in diabetic foot ulcer (DFU). Staphylococcus aureus can colonize DFU, or invade the underlying tissues, causing serious infections. The ROSA-like prophage has previously been implicated in strain colonization characteristics of S aureus isolates in uninfected ulcers. In this study, we investigated this prophage in the S aureus-colonizing strain using an in vitro chronic wound medium mimicking the chronic wound environment. Chronic wound medium reduced bacterial growth and increased biofilm formation and virulence in a zebrafish model. The ROSA-like prophage promoted intracellular survival of S aureus-colonizing strain in macrophages, keratinocytes, and osteoblasts.
Medical subject headings
- Diabetic Foot
- Staphylococcal Infections