Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37343201.
- Also identified by DOI 10.1200/PO.23.00132 and PMC identifier 10309572.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and deeper understanding of genetic subtypes of CH are yielding insights into the tumor-immune interface that may help to explain the heterogeneous impact of CH on tumorigenesis and treatment. Herein, we update the expanding influence of CH in precision oncology and propose important research and clinical questions to address to effectively manage and harness CH in oncology patients.
Medical subject headings
- Neoplasms