RORing toward immunoregulation in glomerulonephritis?
review · Level V
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- Record sourced from PubMed, PMID 37349057.
- Also identified by DOI 10.1016/j.kint.2023.04.018.
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Abstract
CD4<sup>+</sup> T cells that express forkhead box protein 3 are important in maintaining tolerance and restraining effector responses. Herrnstadt et al. use a model of rapidly progressive glomerulonephritis to examine the nature and role of forkhead box protein 3-positive and retinoid acid-related orphan receptor γt-positive regulatory T cells. These cells are prominent in experimental glomerulonephritis, both locally and systemically, and are present in kidneys of people with anti-neutrophil cytoplasmic antibody-associated vasculitis. Functionally, despite their expression of retinoid acid-related orphan receptor γt, associated with T-helper cell 17 cells, they regulate cellular immunity, both systemically and within the kidney.
Medical subject headings
- Glomerulonephritis