Maybe the various forms of kidney disease are not so mechanistically different?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37349058.
- Also identified by DOI 10.1016/j.kint.2023.04.014.
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Abstract
Sieckmann and colleagues provide evidence of a common abnormality in polyamine metabolism in 11 different rodent models of acute kidney injury and chronic kidney disease, and in human renal transplantation. The abnormality is characterized by downregulation of enzymes involved in polyamine synthesis and/or upregulation of enzymes involved in polyamine metabolism. Therefore, polyamine metabolism is a potential target for development of pharmacotherapies for a broad range of kidney diseases.
Medical subject headings
- Polyamines
- Acute Kidney Injury