Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 37380166.
- Also identified by DOI 10.1093/infdis/jiad245 and PMC identifier 10786252.
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Abstract
Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants had detectable virus-specific T-cell responses, including a PWH who was not on antiretroviral therapy and a PWH on immunosuppressive therapy. These 2 participants had robust polyfunctional CD4+ T-cell responses to peptides from the 121L vaccinia virus (VACV) protein. T-cells from 4 of 5 HLA-A2-positive participants targeted at least 1 previously described HLA-A2-restricted VACV epitope, including an epitope targeted in 2 participants. These results advance our understanding of immunity in convalescent Mpox patients.
Medical subject headings
- Orthopoxvirus
- Mpox, Monkeypox