The landscape of infantile epileptic spasms syndrome in South Asia: peculiarities, challenges, and way forward.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37384052.
- Also identified by DOI 10.1016/j.lansea.2023.100170 and PMC identifier 10306027.
- Licence recorded as CC BY-NC-ND.
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Abstract
Infantile Epileptic Spasms Syndrome (IESS), commonly known as West syndrome, is the most common cause of infantile-onset epileptic encephalopathy. There is a peculiar epidemiological profile of IESS in South Asia. Specific features identified were a preponderance of acquired structural aetiology, male gender dominance, a long treatment lag, limited availability of adrenocorticotropic hormone (ACTH) and vigabatrin, and use of carboxymethyl cellulose derivative of ACTH. Because of the significant disease burden and limited resources, there are distinctive challenges to the optimal care of children with IESS in the South Asian region. Also, there are unique opportunities to bridge these challenges and improve outcomes. This review provides an overview of the landscape of IESS in South Asia and highlights its peculiarities, various challenges, and way forward.