The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37385377.
- Also identified by DOI 10.1016/j.radonc.2023.109767 and PMC identifier 11045040.
- Licence recorded as CC BY-NC-ND.
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Abstract
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.
Medical subject headings
- Neuronal Plasticity
- Long-Term Potentiation