MultiVI: deep generative model for the integration of multimodal data.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37386189.
- Also identified by DOI 10.1038/s41592-023-01909-9 and PMC identifier 10406609.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Jointly profiling the transcriptome, chromatin accessibility and other molecular properties of single cells offers a powerful way to study cellular diversity. Here we present MultiVI, a probabilistic model to analyze such multiomic data and leverage it to enhance single-modality datasets. MultiVI creates a joint representation that allows an analysis of all modalities included in the multiomic input data, even for cells for which one or more modalities are missing. It is available at scvi-tools.org .
Medical subject headings
- Models, Statistical
- Transcriptome