Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37390822.
- Also identified by DOI 10.1016/j.cmet.2023.06.003 and PMC identifier 10527949.
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Abstract
Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we review immune-related functions of core metabolic pathways, key metabolites, and crucial nutrient transporters in the TME, discuss their metabolic, signaling, and epigenetic impact on tumor immunity and immunotherapy, and explore how these insights can be applied to the development of more effective modalities to potentiate the function of T cells and sensitize tumor cell receptivity to immune attack, thereby overcoming therapeutic resistance.
Medical subject headings
- Tumor Microenvironment
- Neoplasms