PET Imaging of Nectin-4: A Promising Tool for Personalized/Precision Oncology.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 37417960.
- Also identified by DOI 10.1158/1078-0432.CCR-23-1243 and PMC identifier 10529329.
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Abstract
In a recent study, the authors developed a nectin-4-targeting bicyclic peptide-based radiotracer, 68Ga-N188, for PET imaging of advanced urothelial cancer. Preclinical investigation and first-in-human study in 14 patients demonstrated excellent specificity and sensitivity of 68Ga-N188 in detecting metastases. These promising results support 68Ga-N188 as a companion diagnostic for future personalized cancer therapy. See related article by Duan et al., p. 3395.
Medical subject headings
- Carcinoma, Transitional Cell
- Urinary Bladder Neoplasms