Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37419102.
- Also identified by DOI 10.1016/j.stem.2023.05.013 and PMC identifier 10505011.
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Abstract
It remains challenging to create a physiologically relevant human-brain-like environment that would support maturation of human pluripotent stem cell (hPSC)-derived microglia (hMGs). Schafer et al.<sup>1</sup> (Cell, 2023) now develop an in vivo neuroimmune organoid model with mature homeostatic hMGs for the study of brain development and disease.
Medical subject headings
- Microglia
- Pluripotent Stem Cells