Chromatin-transcription interface: The secret of eternal youth?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37427688.
- Also identified by DOI 10.1111/acel.13927 and PMC identifier 10497848.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In their recent study in Nature, Debès et al. report an increase in RNA polymerase II (Pol II)-mediated transcriptional elongation speed associated with chromatin remodeling during aging in four metazoan animals, two human cell lines, and human blood. Their findings might help us understand why we age through evolutionarily conserved essential processes, and open a window to the molecular and physiological mechanisms influencing healthspan, lifespan and/or longevity.
Medical subject headings
- Chromatin
- RNA Polymerase II