Beyond Neoantigens: Antigens Derived from Tumor Drivers as Cancer Vaccine Targets.
Where this comes from
- Record sourced from PubMed, PMID 37428103.
- Also identified by DOI 10.1158/1078-0432.CCR-23-1244 and PMC identifier 10472089.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A vaccine targeting HER2, a nonmutated but overexpressed tumor antigen, readily primed T cells for ex vivo expansion and adoptive transfer with minimal toxicity. This regimen led to intramolecular epitope spreading in a majority of patients and offers a treatment modality that may improve outcomes for patients with metastatic breast cancer expressing HER2. See related article by Disis et al., p. 3362.
Medical subject headings
- Breast Neoplasms
- Cancer Vaccines