Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies.
Where this comes from
- Record sourced from PubMed, PMID 37433789.
- Also identified by DOI 10.1038/s41467-023-39777-8 and PMC identifier 10336004.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Protein lysine methylation plays important biological roles but its experimental characterization is limited by the lack of suitable mimetics of methylated and unmethylated lysine among the natural amino acids. Here, we summarize the consequent challenges and discuss alternative approaches for biochemical and cellular lysine methylation studies.
Medical subject headings
- Amino Acids
- Lysine