CLA+ memory T cells in atopic dermatitis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37439317.
- Also identified by DOI 10.1111/all.15816.
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Abstract
Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)<sup>+</sup> T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA<sup>+</sup> T cell mechanisms in atopic dermatitis patients. The function of CLA<sup>+</sup> T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
Medical subject headings
- Dermatitis, Atopic