Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience.

Turcas, Andrada; Kelly, Sarah M; Bernier-Chastagner, Valérie; Bolle, Stephanie; Cameron, Alison; Corning, Coreen; Clementel, Enrico; Dieckmann, Karin et al. · Radiother Oncol · 2023

retrospective_cohort · Level III

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Abstract

Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

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