Innate immune sensing by cGAS-STING in animals reveals unexpected messengers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37478819.
- Also identified by DOI 10.1016/j.cell.2023.06.014.
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Abstract
The DNA sensor cGAS and its adaptor STING constitute an ancient pathogen detection mechanism, but it is unclear to what extent its function is conserved across the animal kingdom. In this issue of Cell, Kranzusch and colleagues identify thousands of cGAS-like receptors and discover networks of second messengers that activate innate immune responses in animals.
Medical subject headings
- Signal Transduction
- Membrane Proteins