Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37479383.
- Also identified by DOI 10.1016/j.kint.2023.04.016.
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Abstract
The pathogenic mechanisms of acquired focal and segmental glomerular sclerosis are only partially known and represent a medical challenge in nephrology. The article by May et al. sheds additional light on previous data indicating the key role of the protease-activated receptor 1. The new evidence is based on in vivo studies in relevant animal models and on patient biopsies and represents a significant step forward in the understanding of this pathologic condition.
Medical subject headings
- Receptor, PAR-1
- Glomerulosclerosis, Focal Segmental