Canakinumab in addition to phosphate-binding and phosphaturia-inducing therapy were effective in achieving remission in a child with a large familial calcinotic tumour.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 37520934.
- Also identified by DOI 10.1016/j.bonr.2023.101695 and PMC identifier 10372364.
- Licence recorded as CC BY-NC-ND.
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Abstract
We describe the clinical evolution of a patient with tumoral calcinosis due to a pathogenic variant in the <i>GALNT3</i> gene presented with a large mass overlying her left hip associated complicated by inflammatory flares. Therapy (sevelamer, acetazolamide, and probenecid) was unsuccessful in preventing tumour surgeries, therefore, interleukin-1β monoclonal antibody therapy was added; this was successful in the prevention of tumour re-growth. This case highlights the importance of assessing and treating the inflammatory aspect of calcinotic tumour.