In uncontrolled T2DM treated with a basal-bolus insulin regimen, weekly icodec was noninferior to daily glargine for HbA<sub>1c</sub> at 26 wk.

Belal, Heiba; Gandhi, Gunjan Y · Ann Intern Med · 2023

rct · Level II

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Abstract

Mathieu C, Ásbjörnsdóttir B, Bajaj HS, et al. <b>Switching to once-weekly insulin icodec versus once-daily insulin glargine U100 in individuals with basal-bolus insulin-treated type 2 diabetes (ONWARDS 4): a phase 3a, randomised, open-label, multicentre, treat-to-target, non-inferiority trial.</b> Lancet. 2023;401:1929-1940. 37156252.

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