Peptide YY: A Paneth cell antimicrobial peptide that maintains <i>Candida</i> gut commensalism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37535745.
- Also identified by DOI 10.1126/science.abq3178 and PMC identifier 10876062.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY<sub>1-36</sub>), but not endocrine PYY<sub>3-36</sub>, acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent <i>Candida albicans</i> hyphae-but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.
Medical subject headings
- Antifungal Agents
- Antimicrobial Peptides
- Candida
- Paneth Cells
- Peptide Fragments
- Peptide YY