Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37537178.
- Also identified by DOI 10.1038/s41536-023-00318-y and PMC identifier 10400583.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing floxed gene alleles. Here we generated Cre-activated functional ProTracer (fProTracer) mice, which enable simultaneous recording of cell proliferation and tissue-specific gene deletion, facilitating broad functional analysis of cell proliferation by any Cre driver.