Unveiling TMEM106B: SARS-CoV-2's secret entrance to the cell.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37541193.
- Also identified by DOI 10.1016/j.cell.2023.07.005.
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Abstract
The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2 infection, though it was not known how. In this issue of Cell, Baggen et al. demonstrate that TMEM106B serves as an ACE2-independent receptor for SARS-CoV-2 entry by promoting the fusion of the viral membrane with the lysosomal membrane.
Medical subject headings
- SARS-CoV-2
- COVID-19