Replacing microglia to treat Alzheimer's disease.
editorial · Level V
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- Record sourced from PubMed, PMID 37541204.
- Also identified by DOI 10.1016/j.stem.2023.07.005 and PMC identifier 10542828.
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Abstract
In this issue of Cell Stem Cell, Yoo et al.<sup>1</sup> report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer's disease treatment.
Medical subject headings
- Alzheimer Disease