Complement.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37551641.
- Also identified by DOI 10.1002/art.42671.
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Abstract
The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized by immune-complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications.
Medical subject headings
- Complement C4
- Complement C3