Activatable Semiconducting Polymer Nanoinducers Amplify Oxidative Damage via Sono-Ferroptosis for Synergistic Therapy of Bone Metastasis.
basic_science · Level V
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- Record sourced from PubMed, PMID 37565802.
- Also identified by DOI 10.1021/acs.nanolett.3c02414.
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Abstract
Bone metastases are secondary malignant tumors that commonly occur after the spread of advanced cancer cells. We herein report the activatable semiconducting polymer nanoinducers (ASPN<sub>FP</sub>) that can amplify oxidative damage via sono-ferroptosis for bone metastasis treatment. ASPN<sub>FP</sub> are constructed by encapsulating plasma amine oxidase-based semiconducting polymer nanoparticles (SPN<sub>P</sub>) and Fe<sub>3</sub>O<sub>4</sub> nanoparticles into singlet oxygen (<sup>1</sup>O<sub>2</sub>)-responsive nanocarriers. ASPN<sub>FP</sub> generate <sup>1</sup>O<sub>2</sub> under ultrasound (US) irradiation via a sonodynamic effect to destroy the stability of <sup>1</sup>O<sub>2</sub>-responsive nanocarriers, allowing US-triggered releases of SPN<sub>P</sub> and Fe<sub>3</sub>O<sub>4</sub> nanoparticles. SPN<sub>P</sub> decompose polyamines in tumor cells to produce acrolein and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), in which H<sub>2</sub>O<sub>2</sub> promotes Fenton reaction mediated by Fe<sub>3</sub>O<sub>4</sub> nanoparticles for inducing enhanced ferroptosis and generation of hydroxyl radicals (•OH). The generated acrolein, <sup>1</sup>O<sub>2</sub>, and •OH can simultaneously amplify the oxidative damage. ASPN<sub>FP</sub> thus mediate an amplified sono-ferroptosis effect to inhibit the growth of bone metastasis and restrict tumor metastasis.
Medical subject headings
- Ferroptosis
- Bone Neoplasms
- Nanoparticles
- Neoplasms