AARDVARK: an automated reversion detector for variants affecting resistance kinetics.
Where this comes from
- Record sourced from PubMed, PMID 37584701.
- Also identified by DOI 10.1093/bioinformatics/btad509 and PMC identifier 10457659.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Resistance to two classes of FDA-approved therapies that target DNA repair-deficient tumors is caused by mutations that restore the tumor cell's DNA repair function. Identifying these "reversion" mutations currently requires manual annotation of patient tumor sequence data. Here we present AARDVARK, an R package that automatically identifies reversion mutations from DNA sequence data. AARDVARK is implemented in R (≥3.5). It is available on GitHub at https://github.com/davidquigley/aardvark. It is licensed under the MIT license.
Medical subject headings
- Software
- DNA