Population-wide analysis of hospital laboratory tests to assess seasonal variation and temporal reference interval modification.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 37602220.
- Also identified by DOI 10.1016/j.patter.2023.100778 and PMC identifier 10435957.
- Licence recorded as CC BY-NC-ND.
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Abstract
We identified mortality-, age-, and sex-associated differences in relation to reference intervals (RIs) for laboratory tests in population-wide data from nearly 2 million hospital patients in Denmark and comprising more than 300 million measurements. A low-parameter mathematical wave-based modification method was developed to adjust for dietary and environment influences during the year. The resulting mathematical fit allowed for improved association rates between re-classified abnormal laboratory tests, patient diagnoses, and mortality. The study highlights the need for seasonally modified RIs and presents an approach that has the potential to reduce over- and underdiagnosis, affecting both physician-patient interactions and electronic health record research as a whole.