Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs.

Lotia Farrukh, Ismat; Lachenal, Nathalie; Adenov, Malik M; Ahmed, Saman; Algozhin, Yerkebulan; Coutisson, Sylvine; Garavito, Epifanio Sánchez; Hewison, Catherine et al. · Clin Infect Dis · 2024

case_series · Level IV

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Abstract

Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of 31 continued pregnancies, 81% had live births with no reported malformations, and 68% of neonates had normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.

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