Risk of Parkinson's Disease in Celiac Disease: A Swedish Population-Based Study.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 37632335.
- Also identified by DOI 10.1002/ana.26780.
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Abstract
Using a population-based matched cohort design, we assessed the association of celiac disease (CeD) with risk of PD by comparing patients with biopsy-confirmed CeD in Sweden to a biopsy-free population and their unaffected siblings, separately. No overall association was observed but CeD diagnosed before age 60 associated positively with incident diagnosis of PD (hazard ratio [HR] = 1.29; 95% confidence interval [CI]: 1.02-1.62), which was mainly attributed to the significantly elevated risk detected after 10-15 years since biopsy (HR = 1.68; 95% CI: 1.05-2.68). Our findings imply an increased vulnerability to long-term PD development among patients with CeD diagnosed before 60s. ANN NEUROL 2023;94:911-916.
Medical subject headings
- Celiac Disease
- Parkinson Disease