Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy.
case_report · Level V
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- Record sourced from PubMed, PMID 37647624.
- Also identified by DOI 10.1093/cid/ciad517.
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Abstract
We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.
Medical subject headings
- Melioidosis
- Burkholderia pseudomallei
- Extracorporeal Membrane Oxygenation