DCAlign v1.0: aligning biological sequences using co-evolution models and informed priors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37647658.
- Also identified by DOI 10.1093/bioinformatics/btad537 and PMC identifier 10491954.
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Abstract
DCAlign is a new alignment method able to cope with the conservation and the co-evolution signals that characterize the columns of multiple sequence alignments of homologous sequences. However, the pre-processing steps required to align a candidate sequence are computationally demanding. We show in v1.0 how to dramatically reduce the overall computing time by including an empirical prior over an informative set of variables mirroring the presence of insertions and deletions. DCAlign v1.0 is implemented in Julia and it is fully available at https://github.com/infernet-h2020/DCAlign.
Medical subject headings
- Sequence Alignment