Neurofilament Light Chain as a Biomarker of Neuronal Damage in Children With Malaria.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 37647876.
- Also identified by DOI 10.1093/infdis/jiad373 and PMC identifier 10786245.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Malaria can cause brain injury. Neurofilament light chain (NfL) is a biomarker of neuronal damage. Here we examined longitudinal plasma NfL levels in children aged 1-12 years with uncomplicated and severe malaria from Mozambique. NfL levels were similar in all malaria cases at hospital admission. However, levels increased over time and the increment was significantly higher in severe malaria cases with neurological manifestations (ie, coma, impaired consciousness, or repeated seizures). NfL may be useful to identify and quantify brain injury in malaria.
Medical subject headings
- Brain Injuries
- Malaria