NeuSort: an automatic adaptive spike sorting approach with neuromorphic models.

Abstract

<i>Objective.</i>Spike sorting, a critical step in neural data processing, aims to classify spiking events from single electrode recordings based on different waveforms. This study aims to develop a novel online spike sorter, NeuSort, using neuromorphic models, with the ability to adaptively adjust to changes in neural signals, including waveform deformations and the appearance of new neurons.<i>Approach.</i>NeuSort leverages a neuromorphic model to emulate template-matching processes. This model incorporates plasticity learning mechanisms inspired by biological neural systems, facilitating real-time adjustments to online parameters.<i>Results.</i>Experimental findings demonstrate NeuSort's ability to track neuron activities amidst waveform deformations and identify new neurons in real-time. NeuSort excels in handling non-stationary neural signals, significantly enhancing its applicability for long-term spike sorting tasks. Moreover, its implementation on neuromorphic chips guarantees ultra-low energy consumption during computation.<i>Significance.</i>NeuSort caters to the demand for real-time spike sorting in brain-machine interfaces through a neuromorphic approach. Its unsupervised, automated spike sorting process makes it a plug-and-play solution for online spike sorting.