Spatial multimodal analysis of transcriptomes and metabolomes in tissues.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37667091.
- Also identified by DOI 10.1038/s41587-023-01937-y and PMC identifier 11251988.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson's disease.
Medical subject headings
- Transcriptome
- Metabolome
- Parkinson Disease
- Brain