Manganese-enhanced magnetic resonance imaging reveals light-induced brain asymmetry in embryo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37668506.
- Also identified by DOI 10.7554/eLife.86116 and PMC identifier 10479960.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The idea that sensory stimulation to the embryo (in utero or in ovo) may be crucial for brain development is widespread. Unfortunately, up to now evidence was only indirect because mapping of embryonic brain activity in vivo is challenging. Here, we applied for the first time manganese enhanced magnetic resonance imaging (MEMRI), a functional imaging method, to the eggs of domestic chicks. We revealed light-induced brain asymmetry by comparing embryonic brain activity in vivo of eggs that were stimulated by light or maintained in the darkness. Our protocol paves the way to investigation of the effects of a variety of sensory stimulations on brain activity in embryo.
Medical subject headings
- Manganese
- Brain