Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37672656.
- Also identified by DOI 10.1093/bjd/ljad330 and PMC identifier 10653332.
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Abstract
Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NFκB, TNF, MAPK and cholesterol metabolism, are dysregulated. These data suggest new therapeutics can be developed to target such dysregulated pathways in the treatment of PWB.
Medical subject headings
- Induced Pluripotent Stem Cells
- Port-Wine Stain
- Vascular Malformations