Relaxivity Enhancement of Hybrid Micelles via Modulation of Water Coordination Numbers for Magnetic Resonance Lymphography.
basic_science · Level V
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- Record sourced from PubMed, PMID 37695636.
- Also identified by DOI 10.1021/acs.nanolett.3c02214.
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Abstract
Considerable efforts have been made to develop nanoparticle-based magnetic resonance contrast agents (CAs) with high relaxivity. The prolonged rotational correlation time (τ<sub>R</sub>) induced relaxivity enhancement is commonly recognized, while the effect of the water coordination numbers (<i>q</i>) on the relaxivity of nanoparticle-based CAs gets less attention. Herein, we first investigated the relationship between <i>T</i><sub>1</sub> relaxivity (<i>r</i><sub>1</sub>) and <i>q</i> in manganese-based hybrid micellar CAs and proposed a strategy to enhance the relaxivity by increasing <i>q</i>. Hybrid micelles with different ratios of amphiphilic manganese complex (MnL) and DSPE-PEG2000 were prepared, whose <i>q</i> values were evaluated by Oxygen-17-NMR spectroscopy. Micelles with lower manganese doping density exhibit increased <i>q</i> and enhanced relaxivity, corroborating the conception. <i>In vivo</i> sentinel lymph node (SLN) imaging demonstrates that DSPE-PEG/MnL micelles could differentiate metastatic SLN from inflammatory LN. Our strategy makes it feasible for relaxivity enhancement by modulating <i>q</i>, providing new approaches for the structural design of high-performance hybrid micellar CAs.
Medical subject headings
- Micelles
- Water