Getting an aMPLe grasp on hematopoiesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37714132.
- Also identified by DOI 10.1016/j.cell.2023.08.015.
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Abstract
Hematopoiesis requires balance between self-renewal of stem cells and differentiation into mature blood cells, orchestrated by pathways such as thrombopoietin signaling. In this issue of Cell, Tsutsumi et al. report the structure of the thrombopoietin ligand-receptor complex and demonstrate the potential to decouple its roles in self-renewal and hematopoietic differentiation.
Medical subject headings
- Thrombopoietin
- Hematopoiesis