Cis-regulatory arbitrators of regeneration.

Konieczny, Piotr; Naik, Shruti · Cell Stem Cell · 2023

basic_science · Level V

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Abstract

Mammals favor healing with scaring over functional tissue regeneration.<sup>1</sup> In this issue of Cell Stem Cell, Mack et al. use "super-healer" mice to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regeneration.<sup>2</sup>.

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