The art of chasing numbers in titration of anaesthetic dose.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37718094.
- Also identified by DOI 10.1016/j.bja.2023.07.023.
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Abstract
There is no difference in between-patient variability of concentrations when comparing propofol and sevoflurane titrated to a bispectral index of 40-60. There is about a 300% variation in hypnotic concentration between the bottom 5% and top 5% of the population. Anaesthesia titration cannot be based solely on measured or estimated drug concentrations.
Medical subject headings
- Anesthetics
- Anesthesia
- Anesthesiology
- Propofol