A framework for intestinal barrier dysfunction in aging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37723210.
- Also identified by DOI 10.1038/s43587-023-00492-0 and PMC identifier 12778930.
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Abstract
The intestinal epithelium serves as a barrier that facilitates interaction between intrinsic and environmental factors. Aging is accompanied by the gradual deterioration of this barrier. We postulate that barrier dysfunction results from defects in epithelial membrane trafficking that exacerbate age-related metabolic imbalances. Herein, we integrate barrier integrity, protein homeostasis, membrane trafficking and intracellular lipid sensing into an age-determining mechanism.
Medical subject headings
- Intestinal Diseases
- Gastrointestinal Diseases